NES Paul - Hacked Guitar + Nintendo
When I say "hacked" I mean hacked! If you visit the page linked below you'll see that while conventional tools were employed to modify both a guitar and a classic NES console, the creator did have to press a giant machette into use as well. Whoa.
You may recall that Music Thing featured a similar project guitar, except that axe was 16-bit since it was based on a Sega Genesis. It's hard to think that either guitar sounds very good, but given the amount of digital jiggery-pokery that you can process your guitar's output through, I imagine that these plastic & pulpwood guitars have a chance of sounding okay. A silk purse from a sow's DSP, if you will...